SS-31 + MOTS-c Mitochondrial Research Stack | QSC

QSC · RESEARCH CATALOG

SS-31 + MOTS-c Mitochondrial Research Stack
Cardiolipin IMM Protection + AMPK Metabolic Activator · Dual Mitochondrial Pathway · ≥99% HPLC · Janoshik COA

SS-31 (Elamipretide) and MOTS-c represent two distinct and non-overlapping mitochondrial research pathways. SS-31 targets the inner mitochondrial membrane directly via cardiolipin binding — preserving electron transport chain efficiency and reducing ROS. MOTS-c signals from mitochondrial DNA to activate AMPK — improving metabolic flexibility, insulin sensitivity, and cellular stress resistance. Together they provide the broadest mitochondrial research coverage available in a single protocol.

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≥99%
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Janoshik
Independent COA
US-Based
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SS-31 (Elamipretide): Inner Mitochondrial Membrane Protection

SS-31 (D-Arg-Dmt-Lys-Phe-NH2) concentrates 1000× in the IMM via electrostatic attraction to cardiolipin. Mechanism:

  • Cardiolipin binding → stabilizes cristae structure → maintains IMM surface area for ATP synthase
  • Cardiolipin-cytochrome c interaction stabilization → prevents cytochrome c release → anti-apoptotic
  • Complex I/II electron transport efficiency preservation → higher ATP output, lower ROS
  • Studied in heart failure (HOPE-3 Phase 2 trial), Barth syndrome, neurodegeneration, ischemia-reperfusion

MOTS-c: Mitochondrial-Derived AMPK Activator

MOTS-c (16-mer encoded in 12S rRNA region of mtDNA) translocates to nucleus under stress to activate AMPK. Mechanism:

  • AMPK (AMP-activated kinase) activation → glucose uptake ↑, lipogenesis ↓, FAO ↑
  • Insulin sensitization in skeletal muscle and adipose tissue models
  • Exercise adaptation — blood levels increase with aerobic exercise in human studies
  • Aging model data: MOTS-c declines with age in mouse and human tissue; supplementation extends lifespan in mice

Why Combine SS-31 and MOTS-c?

Compound Target Primary Mechanism Research Application
SS-31 Cardiolipin/IMM Structural IMM protection, ATP efficiency, anti-apoptotic Heart failure, ischemia, neurodegeneration
MOTS-c AMPK/nuclear Metabolic flexibility, insulin sensitivity, stress adaptation Metabolic syndrome, aging, exercise physiology

Frequently Asked Questions

What is the SS-31 + MOTS-c stack?
SS-31 + MOTS-c covers two non-overlapping mitochondrial pathways: structural IMM protection (SS-31) and metabolic AMPK signaling (MOTS-c). Used for comprehensive mitochondrial research protocols. QSC stocks both at ≥99% HPLC with Janoshik COA.
Does QSC stock SS-31?
Yes — QSC stocks SS-31 (Elamipretide, D-Arg-Dmt-Lys-Phe-NH2) at ≥99% HPLC with Janoshik independent COA verifiable at verify.janoshik.com. Research use only.
Does QSC stock MOTS-c?
Yes — QSC stocks MOTS-c (mitochondrial AMPK activator, 16-mer) at ≥99% HPLC with Janoshik COA. One of very few US research suppliers to carry this compound. Research use only.

Shop SS-31 + MOTS-c at QSC

≥99% HPLC · Janoshik COA · US-Based · Research Use Only

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Research Use Only: All QSC products sold strictly for in vitro laboratory research. Not for human or veterinary use.
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