QSC RESEARCH GRADE
≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPS5-Region Domestic Shipping
What is HGH Fragment 176-191?
HGH Fragment 176-191 (Native GH C-terminal fragment — lipolytic peptide) is a 16-amino acid native GH C-terminal fragment. Native C-terminal fragment of human growth hormone (residues 176-191) activating lipolysis via beta-3 adrenergic receptor without GH receptor binding. Adipose-selective lipolytic activity identical mechanistic pathway to AOD-9604 but using the native (non-Tyr modified) sequence.
Research Applications
Native GH Fragment Research
Structure-activity comparison using native vs modified (AOD-9604) sequence
Beta-3 AR Lipolysis
Adipocyte HSL activation, triglyceride hydrolysis, FFA release
No GHR Activation
Adipose-selective activity — no IGF-1, no anabolic GH effects
vs AOD-9604
Native (Frag 176-191) vs modified (Tyr + 177-191) research design
Adipose Biology
Fat cell lipolysis mechanism in adipose tissue models
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 12629-01-5 |
| Molecular Formula | C₈₆H₁₄₄N₂₆O₂₈S |
| Peptide Type | Synthetic Peptide / Growth Hormone Fragment |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
